Douglas K. Bishop

The paper shows that Mek1, a meiotic kinase, limits Exo1-dependent DNA end resection during meiotic recombination in yeast, using a different mechanism than Rad53 in mitosis.

The paper identifies a Dmc1 mutant that bypasses Mei5-Sae3, revealing independent roles of Mei5-Sae3 and Rad51 in Dmc1 filament stability and recombination accuracy.

This study shows that Rad24/Rad17 and Mec1/ATR have distinct roles in regulating meiotic crossovers, with Rad24 affecting CO frequency on shorter chromosomes and Mec1 impacting CO interference.

This study shows RAD51's non-enzymatic roles in replication fork processing and restart, revealing its function in fork reversal and promoting replication restart through both enzymatic and non-enzymatic mechanisms.

The paper shows that RecA's ATPase activity prevents toxic DNA-bound complexes formed by erroneous binding to undamaged dsDNA in E. coli.