Spencer B. Huggett

CONSILIENCE-GWAS integrates functional genomics data with human GWAS to analyze heritability and polygenic scores across species.

This study integrates bulk and single-cell transcriptomic data from humans, primates, and mice to identify overlapping biological processes and cell types associated with alcohol use disorder (AUD) and its models.

This study identifies genetic links between alternative mRNA splicing and alcohol use disorder using RNA-seq and genome-wide association data.

The paper uses cross-species transcriptomic data to identify genetic factors influencing human tobacco consumption, finding heritability enrichment in co-regulated genes.

The paper identifies conserved gene expression patterns between mouse cocaine self-administration and human cocaine use disorder in meso-limbic circuits.

This study shows that including genetic and sex differences in mice improves the alignment of addiction-related traits with human studies.