Jason A. Bubier

This study identifies a novel MHC-linked locus in mice that enhances resistance to gammaherpesvirus infection without relying on NK cells or large cytotoxic T cell expansion.

This study identifies a shared genetic regulator linking metabolism and addiction-related behavior in mice and humans through a common enhancer regulating Eed/Me3 and EED/ME3.

The paper identifies genetic loci affecting cocaine sensitivity in Collaborative Cross mouse strains through QTL mapping and proposes candidate genes for further study.

CONSILIENCE-GWAS integrates functional genomics data with human GWAS to analyze heritability and polygenic scores across species.

The paper examines behavioral variation in cocaine self-administration across multiple phases in genetically diverse mouse populations, identifying strain and sex differences and extreme strains for drug intake traits.

This study identifies and validates 22 genes that drive drug intake and related behavioral traits in mice through knockout screening and behavioral assays.

This study maps eQTLs in the striatum of Diversity Outbred mice and provides tools for querying genetic variants and co-expression networks related to striatal gene expression and addiction-related behaviors.

This study links gut microbiome composition and glutamate metabolism to cocaine self-administration in mice, showing sex-specific associations and functional relevance.

The paper describes five Rorb mutant mouse strains with gait and retinal abnormalities, showing transcriptomic changes linked to neurodevelopmental disorders.

The paper uses cross-species transcriptomic data to identify genetic factors influencing human tobacco consumption, finding heritability enrichment in co-regulated genes.

The paper identifies genetic factors influencing opioid-induced respiratory depression in mice using genetic mapping and functional analysis.

The paper identifies conserved gene expression patterns between mouse cocaine self-administration and human cocaine use disorder in meso-limbic circuits.

The paper identifies Rab3b as a gene influencing cocaine response and habituation in mice through integrative genomic analysis of multiple studies.

This paper introduces NESS, a tool that improves gene-disease association discovery by leveraging multi-species functional genomics data and network analysis to overcome data sparsity and bias.

The paper identifies host-microbiome interactions using systems genetics in mice, revealing mechanisms of microbial involvement in disease.

The paper integrates heterogeneous functional genomics data across species to identify genes and pathways underlying aging, finding Cd63 as a key gene with lifespan-extending effects in C. elegans.

This study identifies a Trpa1 splice junction variant in Diversity Outbred mice that influences late phase formalin response, linking it to pain sensitivity mechanisms.