Rohan H. C. Palmer

CONSILIENCE-GWAS: A Web Resource for Parsed Heritability & Polygenic Score Analysis of Human GWAS Using Heterogeneous Functional Genomics Data

CONSILIENCE-GWAS integrates functional genomics data with human GWAS to analyze heritability and polygenic scores across species.

Bulk and Single-cell Transcriptomic Brain Data Identify Overlapping Processes and Cell-types with Human AUD and Mammalian Models of Alcohol Use

This study integrates bulk and single-cell transcriptomic data from humans, primates, and mice to identify overlapping biological processes and cell types associated with alcohol use disorder (AUD) and its models.

Resting-State Network Analysis of Suicide Attempt History in the UK Biobank

This study compares resting-state functional connectivity between individuals with suicide attempts and those with self-directed violence thoughts using UK Biobank data, finding no significant differences.

Genetic associations among internalizing and externalizing traits with polysubstance use among young adults

The paper investigates genetic associations between internalizing and externalizing traits and polysubstance use, finding unique genetic contributions from externalizing traits.

GWAS of Over 427,000 Individuals Establishes GABAergic and Synaptic Molecular Pathways as Key for Cognitive Executive Functions

This study performs a large-scale GWAS on executive functions, identifying genetic variants linked to synaptic and GABAergic pathways and showing distinct genetic relationships with intelligence and psychiatric disorders.

Genes identified in rodent studies of alcohol intake are enriched for heritability of human substance use

Genome- and Transcriptome-wide Splicing Associations with Problematic Alcohol Use and Alcohol Use Disorder

This study identifies genetic links between alternative mRNA splicing and alcohol use disorder using RNA-seq and genome-wide association data.

Cross-Species Integration of Transcriptomic Effects of Tobacco and Nicotine Exposure Helps to Prioritize Genetic Effects on Human Tobacco Consumption

The paper uses cross-species transcriptomic data to identify genetic factors influencing human tobacco consumption, finding heritability enrichment in co-regulated genes.

Meso-limbic Gene Expression Findings from Mouse Cocaine Self-Administration Recapitulate Human Cocaine Use Disorder

The paper identifies conserved gene expression patterns between mouse cocaine self-administration and human cocaine use disorder in meso-limbic circuits.

Consideration of genetic and sex effects in mice enhances consilience with human addiction studies.

This study shows that including genetic and sex differences in mice improves the alignment of addiction-related traits with human studies.