Lingling Zhang

scPAISO identifies and quantifies alternative polyadenylation sites in scRNA-seq data using Read1, improving PAS detection and isoform quantification accuracy.

This study presents cryo-EM structures of the Cas5-HNH/Cascade complex, revealing its DNA cleavage mechanism and the role of zinc-finger and divalent ions in enzyme activity.

This study shows that a CTCF R567W mutation causes developmental disorders by altering 3D genome structure and neurodevelopmental pathways in mouse and human models.