Lin Wang

SMART: an approach for accurate formula assignment in spatially-resolved metabolomics

SMART improves formula assignment in spatial metabolomics by using a database and regression model, achieving 92.4% accuracy in mouse embryo imaging.

Mutation of an insulin-sensitive Drosophila insulin-like receptor mutant requires methionine metabolism reprogramming to extend lifespan

This paper shows a Drosophila insulin-like receptor mutation extends lifespan by reprogramming methionine metabolism, avoiding insulin resistance and maintaining growth and reproduction.

Structural Basis for RNA-guided DNA degradation by Cas5-HNH/Cascade complex

This study presents cryo-EM structures of the Cas5-HNH/Cascade complex, revealing its DNA cleavage mechanism and the role of zinc-finger and divalent ions in enzyme activity.

Gut bacterial nutrient preferences quantified in vivo

The paper quantifies nutrient preferences of gut bacteria in mice using isotope tracing and finds dietary fiber, protein, and host-derived metabolites drive microbial growth.

Metabolite discovery through global annotation of untargeted metabolomics data

The paper introduces NetID, a global network optimization method for annotating untargeted metabolomics data, identifying novel metabolites in yeast and mouse datasets.

Quantitative fluxomics of circulating metabolites

This study quantifies metabolic fluxes of circulating metabolites in mice using isotope tracing and mass spectrometry to identify major metabolic cycles and their tissue-specific contributions.