Hongtao Zhu

This study characterizes the Ec78 retron system, revealing its dual-enzyme effector complex and the molecular mechanism of phage clearance through cryo-EM structures and functional analysis.

This study presents cryo-EM structures of the Cas5-HNH/Cascade complex, revealing its DNA cleavage mechanism and the role of zinc-finger and divalent ions in enzyme activity.

This study reveals a novel pentameric assembly of tail tube protein in SPR phages using cryo-EM, showing structural features that influence tube curvature and genome release.

The paper identifies three structural populations of GABAARs in mice, revealing how neurosteroids modulate receptor structure and function.

This study investigates the molecular mechanisms of partial agonist action and conformational transitions in the glycine receptor using electrophysiology, MD simulations, and cryo-EM.

The paper presents the cryo-EM structure of a triheteromeric GABAA receptor complexed with GABA, revealing mechanisms of receptor assembly and agonist binding.