Structural Basis for RNA-guided DNA degradation by Cas5-HNH/Cascade complex
Yanan Liu, Lin Wang, Qian Zhang, Pengyu Fu, Lingling Zhang, Ying Yu, Heng Zhang, Hongtao Zhu
This study presents cryo-EM structures of the Cas5-HNH/Cascade complex, revealing its DNA cleavage mechanism and the role of zinc-finger and divalent ions in enzyme activity.
Nature Communications · Feb 4, 2025Peer-reviewedBiophysics