Daniel J Lloyd-Davies Sanchez

NeuroSuite for Long-term Functional and Structural Studies of Air-Liquid Interface Cerebral Organoids

NeuroSuite provides a non-invasive platform for long-term electrophysiological monitoring of brain organoids, revealing neural network development and activity changes.

Modeling Synaptic Maturation from Growth Cone to Synapse in Human Organoids

This study develops a centrifugation protocol to isolate growth cones and immature synapses from human organoids, capturing synaptic development stages and enabling models for studying synaptic function and dysfunction.

Calcium dynamics tune timing of developmental transitions to generate evolutionarily divergent axon tract lengths

The paper shows that slower axon growth in humans, driven by reduced calcium influx, leads to longer axon tracts through prolonged growth duration, with calcium dynamics regulating developmental timing.

Mouse brain organoids model in vivo neurodevelopment and function and capture differences to human

This study develops protocols for generating mouse brain organoids that mimic in vivo neurodevelopment and function, showing they closely resemble in vivo models across multiple readouts.

A minimally guided organoid model for cross-species comparisons of cerebellar development

This study develops a cerebellar organoid model to compare development across species and identifies species-specific size differences and gene expression patterns.

Circadian clocks in human cerebral organoids

This study demonstrates circadian rhythms in human brain cells and organoids, showing they are temperature-compensated and modulated by drugs and cortisol, with implications for chronobiology and brain health.