Author

Joop van den Heuvel

Helmholtz Centre for Infection ResearchORCID 0000-0001-5085-4010Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Adam T. GrundhoffiD· 1 shared Caroline C. FriedeliD· 1 shared Dieter WillboldiD· 1 shared Emanuel WyleriD· 1 shared Florian ErhardiD· 1 shared Hella SchwankeiD· 1 shared Ian GeringiD· 1 shared Jeannine MohrlüderiD· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Adam T. GrundhoffORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintMar 21, 2023

The Cytomegalovirus M35 Protein Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes by Direct Promoter Binding

Hella Schwanke, Vladimir Gonçalves Magalhães, Stefan Schmelz…·Melanie M. Brinkmann

This paper identifies M35 as a viral protein that binds DNA and inhibits IRF3-mediated gene expression, including Ifnb1, thereby suppressing the antiviral type I IFN response.

DOI 10.1101/2023.03.21.533612

mouseDNA methylation

Molecular BiologybioRxivPreprintJul 14, 2021

Conversion rate to the secondary conformation state in the binding mode of SARS-CoV-2 spike protein to human ACE2 may predict infectivity efficacy of the underlying virus mutant

Marc M. Sevenich, Joop van den Heuvel, Ian Gering…·Dieter Willbold

The paper demonstrates that SARS-CoV-2 spike protein binding to ACE2 involves a two-step process with a secondary rate transition that enhances complex stability, and this is also observed in the B.1.1.7 variant.

2 citations

humanprotein structure