Author

Vladimir Gonçalves Magalhães

German Cancer Research CenterORCID 0000-0002-4593-3467Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Adam T. GrundhoffiD· 1 shared Ana Luisa CostaiD· 1 shared Ann-Kathrin MehnertiD· 1 shared Carl HerrmanniD· 1 shared Carla Siebenkotten· 1 shared Carlos Darío RamíreziD· 1 shared Caroline C. FriedeliD· 1 shared Daniel Kirrmaier· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Adam T. GrundhoffORCID

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2 papers

Recent·Most cited

The hepatitis E virus capsid protein ORF2 counteracts cell-intrinsic antiviral responses to enable persistence in hepatocytes

Ann-Kathrin Mehnert, Sebastian Stegmaier, Carlos Darío Ramírez, Vladimir Gonçalves Magalhães, Carla Siebenkotten, Jungen Hu, Ana Luisa Costa, Daniel Kirrmaier, Michael Knop, Xianfang Wu, Thibault Tubiana, Carl Herrmann, Marco Binder, Viet Loan Dao Thi

This study identifies ORF2 as a key HEV protein that suppresses antiviral responses in hepatocytes, enabling viral persistence.

bioRxiv · Feb 3, 2025 · PreprintMicrobiology

The Cytomegalovirus M35 Protein Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes by Direct Promoter Binding

Hella Schwanke, Vladimir Gonçalves Magalhães, Stefan Schmelz, Emanuel Wyler, Thomas Hennig, Thomas Günther, Adam T. Grundhoff, Lars Dölken, Markus Landthaler, Marco van Ham, Lothar Jänsch, Konrad Büssow, Joop van den Heuvel, Wulf Blankenfeldt, Caroline C. Friedel, , Melanie M. Brinkmann

This paper identifies M35 as a viral protein that binds DNA and inhibits IRF3-mediated gene expression, including Ifnb1, thereby suppressing the antiviral type I IFN response.

bioRxiv · Mar 21, 2023 · PreprintMolecular Biology