Author

Hella Schwanke

Helmholtz Centre for Infection ResearchORCID 0000-0001-9252-3594Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Adam T. GrundhoffiD· 2 shared Caroline C. FriedeliD· 2 shared Melanie M. BrinkmanniD· 2 shared Thomas GüntheriD· 2 shared Carola Schneider· 1 shared Claudia S. SchmidtiD· 1 shared Denise OhnezeitiD· 1 shared Emanuel WyleriD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMolecular Biology

Adam T. GrundhoffORCID

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2 papers

Recent·Most cited

Molecular BiologyPLoS PathogensPeer-reviewedAug 7, 2024

Merkel cell polyomavirus small tumor antigen contributes to immune evasion by interfering with type I interferon signaling

Denise Ohnezeit, Jiabin Huang, Ute Westerkamp…·Nicole Fischer

This study identifies a novel function of MCPyV small T antigen in suppressing the type I interferon response by reducing IRF9 levels, impacting immune evasion and tumor progression.

14 citations

humanbulk RNA-seq

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Molecular BiologybioRxivPreprintMar 21, 2023

The Cytomegalovirus M35 Protein Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes by Direct Promoter Binding

Hella Schwanke, Vladimir Gonçalves Magalhães, Stefan Schmelz…·Melanie M. Brinkmann

This paper identifies M35 as a viral protein that binds DNA and inhibits IRF3-mediated gene expression, including Ifnb1, thereby suppressing the antiviral type I IFN response.

DOI 10.1101/2023.03.21.533612

mouseDNA methylation

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