Author

Stefan Schmelz

Helmholtz Centre for Infection ResearchORCID 0000-0002-2511-7593Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Wulf BlankenfeldtiD· 2 shared Adam T. GrundhoffiD· 1 shared Angela MiguriD· 1 shared Anuja KibeiD· 1 shared Caroline C. FriedeliD· 1 shared Chase L. BeiseliD· 1 shared Emanuel WyleriD· 1 shared Florian ErhardiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Wulf BlankenfeldtORCID

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2 papers

Recent·Most cited

BiochemistryMolecular CellPeer-reviewedFeb 17, 2025

AcrVIB1 inhibits CRISPR-Cas13b immunity by promoting unproductive crRNA binding accessible to RNase attack

Katharina G. Wandera, Stefan Schmelz, Angela Migur…·Chase L. Beisel

This paper shows AcrVIB1 inhibits CRISPR-Cas13b by promoting unproductive crRNA binding and degradation, revealing a mechanism to suppress immune defense.

7 citations

CRISPR screenexperimental assay

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Molecular BiologybioRxivPreprintMar 21, 2023

The Cytomegalovirus M35 Protein Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes by Direct Promoter Binding

Hella Schwanke, Vladimir Gonçalves Magalhães, Stefan Schmelz…·Melanie M. Brinkmann

This paper identifies M35 as a viral protein that binds DNA and inhibits IRF3-mediated gene expression, including Ifnb1, thereby suppressing the antiviral type I IFN response.

DOI 10.1101/2023.03.21.533612

mouseDNA methylation

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