Chris Todd Hittinger

CRISpy-pop designs and predicts CRISPR/Cas9 guide RNA activity across diverse yeast and bacterial strains, including human genome cross-referencing for biosafety.

The paper constructs six-species synthetic yeast hybrids and shows they are chromosomally unstable but can rapidly adapt to novel environments.

The paper analyzes the genomic diversity and global distribution of Saccharomyces eubayanus, identifying population structure and climatically suitable regions.

The paper shows how a novel maltotriose transporter evolved in Saccharomyces eubayanus through recombination of non-functional transporter genes, enabling maltotriose consumption.

The paper shows that the mitochondrial genome origin determines temperature tolerance in lager-brewing yeast hybrids.

The paper shows that fructophilic yeasts in the W/S clade lost and reacquired alcoholic fermentation genes via horizontal gene transfer, adapting to high sugar environments.

iWGS is a computational pipeline that guides the design and analysis of de novo genome sequencing projects by simulating data generation, quality control, assembly, and evaluation.

This paper reconstructs the Saccharomycotina yeast phylogeny using genome-scale data from 86 yeast genomes and identifies robust and conflicting relationships among major lineages.

The paper identifies homoploid hybrid speciation in Saccharomyces paradoxus yeast through chromosomal rearrangements and hybridization following secondary contact.