Arunima Biswas

This paper investigates rolipram's inhibition of MMP2/9 beyond its PDE4 activity, showing it affects MMP enzymatic activity and stability through direct protein binding.

Rolipram inhibits hedgehog signaling by promoting ubiquitination and degradation of GLI2FL and GLI3FL, reducing GLI1 levels and tumor growth in breast cancer models.

This study identifies sorafenib and imatinib as potential anti-leishmanial drugs by targeting Leishmania MAP kinases, showing anti-proliferative effects and reduced parasitic burden.

The paper designs combinatorial multiepitope vaccines against scrub typhus using immunoinformatics, identifying conserved epitopes and simulating immune responses.