Author

Janik Weckesser

Goethe University FrankfurtORCID 0000-0001-5100-2776Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

Martin P. SchwalmiD· 2 shared Stefan KnappiD· 2 shared Andreas KrämeriD· 1 shared Anja DölleiD· 1 shared Christian MünchiD· 1 shared Georg TascheriD· 1 shared Gina GotthardtiD· 1 shared Giulio FerrarioiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCell Biology

Martin P. SchwalmORCID

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2 papers

Recent·Most cited

Cell BiologyEMBO ReportsPeer-reviewedOct 16, 2025

The cysteine-reactive covalent RNF4 ligand CCW16 induces ferroptosis in AML cells by activation of ROS signaling

Gina Gotthardt, Janik Weckesser, Georg Tascher…·Stefan P Müller

This study shows that the RNF4 ligand CCW16 induces ferroptosis in AML cells through a RNF4-independent mechanism by causing covalent protein modifications and upregulating ferroptosis markers.

3 citations

humanproteomics

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Molecular BiologyCell chemical biologyPeer-reviewedJun 24, 2023

Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization

Martin P. Schwalm, Andreas Krämer, Anja Dölle…·Stefan Knapp

This paper develops cell-based assays to monitor PROTAC degradation kinetics and ternary complex formation, revealing that ternary complex stability is critical for PROTAC efficiency.

103 citationstop 1%

humanproteomics

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