Mathieu Boulard

This study identifies TRIM66 as a key factor enforcing monogenic expression of olfactory receptors through epigenetic silencing of super-enhancers, impacting axonal projections and behavior.

This study shows that reducing OGT activity in mice causes embryonic lethality proportional to the reduction in O-GlcNAc modification, with milder reductions causing developmental delays and retrovirus activation.

This study shows that Trim66 deficiency in male mice leads to paternal transmission of intrauterine overgrowth in offspring.

This study removes O-GlcNAc from mouse preimplantation embryos and finds it slows embryonic growth without affecting genome activation.