Author

Sara Formichetti

Heidelberg UniversityORCID 0000-0002-7907-2239Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Agnieszka SadowskaiD· 2 shared Mathieu BoulardiD· 2 shared Ana BoškovićiD· 1 shared Christophe LancriniD· 1 shared Daniel SchwabeiD· 1 shared Jan Philipp JunkeriD· 1 shared Julia HanseniD· 1 shared Kerstin GanteriD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersDevelopmental Biology

Agnieszka SadowskaORCID

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3 papers

Recent·Most cited

Genetic gradual reduction of OGT activity unveils the essential role of O-GlcNAc in the mouse embryo

Sara Formichetti, Agnieszka Sadowska, Michela Ascolani, Julia Hansen, Kerstin Ganter, Christophe Lancrin, Neil E. Humphreys, Mathieu Boulard

This study shows that reducing OGT activity in mice causes embryonic lethality proportional to the reduction in O-GlcNAc modification, with milder reductions causing developmental delays and retrovirus activation.

PLoS Genetics · Jan 9, 2025Peer-reviewedDevelopmental Biology

Perturbing nuclear glycosylation in the mouse preimplantation embryo slows down embryonic growth

Sara Formichetti, Urvashi Chitnavis, Agnieszka Sadowska, Na Liu, Ana Bošković, Mathieu Boulard

This study removes O-GlcNAc from mouse preimplantation embryos and finds it slows embryonic growth without affecting genome activation.

bioRxiv · Jan 22, 2024 · PreprintDevelopmental Biology

The transcriptome dynamics of single cells during the cell cycle

Daniel Schwabe, Sara Formichetti, Jan Philipp Junker, Martin Falcke, Nikolaus Rajewsky

The paper reveals that cells move in a circular trajectory in transcriptome space during the cell cycle, minimizing transcriptional changes.

Molecular Systems Biology · Nov 1, 2020Peer-reviewedSystems Biology