Agnieszka Sadowska

This study identifies TRIM66 as a key factor enforcing monogenic expression of olfactory receptors through epigenetic silencing of super-enhancers, impacting axonal projections and behavior.

This study shows that reducing OGT activity in mice causes embryonic lethality proportional to the reduction in O-GlcNAc modification, with milder reductions causing developmental delays and retrovirus activation.

This study removes O-GlcNAc from mouse preimplantation embryos and finds it slows embryonic growth without affecting genome activation.