Author

Rima Singh

University of California, IrvineORCID 0000-0002-6822-7987Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Christopher J. HalbrookiD· 3 shared Alexander KlegeriD· 2 shared Alica K. Beutel· 2 shared Austin D. SilvaiD· 2 shared Cecily AnarakiiD· 2 shared Eleni ZimmeriD· 2 shared Natalie Yousefian· 2 shared Sabrina E. Calderon· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersCancer Biology

Christopher J. HalbrookORCID

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3 papers

Recent·Most cited

Comparative Analysis of Primary and Liver Fibroblasts Reveals MET as a Potent Target in Pancreatic Cancer Metastasis

Rima Singh, Natalie Yousefian, Walker M. Allen, Austin D. Silva, Cecily Anaraki, Alica K. Michels, Sabrina E. Calderon, Ian M. Loveless, Daniella Rastelli, Ashley George, Mohammed Aldakkak, Oliver G. McDonald, Nikki K. Lytle, Jennifer P. Morton, Reed I. Ayabe, , Christopher J. Halbrook

The paper compares primary and liver PDAC lesions using single-cell transcriptomics to identify MET as a target in pancreatic cancer metastasis.

Cellular and Molecular Gastroenterology and Hepatology · Sep 5, 2026Peer-reviewedCancer Biology

Mevalonate Biosynthesis is a Metabolic Vulnerability of Gemcitabine-resistant Pancreatic Cancer

Alica K. Beutel, Sabrina E. Calderon, Ethan Nghiem, Kevin Christian Montecillo Gulay, Leonor Patricia Schubert Santana, Eleni Zimmer, Rima Singh, Cecily Anaraki, Natalie Yousefian, Chantal Allgöwer, Gregory Tong, Cameron Geller, Alina Chao, Dennis Juarez, Thomas Theodor Werner Seufferlein, , Christopher J. Halbrook

This study identifies mevalonate biosynthesis as a therapeutic target and biomarker for gemcitabine-resistant pancreatic cancer.

bioRxiv · Sep 19, 2025 · PreprintCancer Biology

Exploiting TGF-β-mediated Stromal Programming in Homologous Recombination-Deficient Pancreatic Cancer

Élodie Roger, Hannah M Mummey, Eleni Zimmer, Dharini Srinivasan, Anna Härle, Loïc Moubri, Alica K. Beutel, Rima Singh, Menar Ekizce, Michael Karl Melzer, Yun Jung Lee, Austin Silva, Luisa Härle, Thomas Engleitner, Frank Arnold, , Alexander Kleger

This study shows that ATM-deficient pancreatic cancers reprogram the tumor microenvironment via TGF-β-driven myCAF enrichment, and targeting this stromal axis with chemotherapy improves therapeutic efficacy.

bioRxiv · Sep 16, 2025 · PreprintCancer Biology