Author

Saı̈d M. Sebti

Virginia Commonwealth UniversityORCID 0000-0001-5163-1038Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1 Approach:statistical model· 1

Frequent Co-Authors

A’ishah Bakayoko· 2 shared David A. FrumaniD· 2 shared Gerald B. W. WertheimiD· 2 shared Madhuri PauliD· 2 shared Marisa Kruidenier· 2 shared Martin P CarrolliD· 2 shared Roberta BuonoiD· 2 shared Sarah J. SkuliiD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

A’ishah Bakayoko

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 27, 2025

Pitavastatin counteracts venetoclax resistance mechanisms in acute myeloid leukemia by depleting geranylgeranyl pyrophosphate

Roberta Buono, Dennis Juarez, Madhuri Paul…·David A. Fruman

This study shows pitavastatin overcomes venetoclax resistance in AML by depleting GGPP, inducing apoptosis through PUMA upregulation and MCL-1 reduction, and suppressing mitochondrial metabolism.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologyLeukemiaPeer-reviewedJul 9, 2025

Chemoresistance of TP53 mutant AML requires the mevalonate byproduct, GGPP, for regulation of ROS and induction of a mitochondria stress response

Sarah J. Skuli, A’ishah Bakayoko, Marisa Kruidenier…·Martin P Carroll

This study identifies GGPP, a mevalonate pathway byproduct, as critical for chemoresistance in TP53mut AML through ROS regulation and mitochondria stress response, suggesting statin-based therapies could be effective.

12 citationstop 2%

humanbulk RNA-seq

𝕏 PostBluesky