Sven Larsen-Ledet

The paper maps over 20,000 human protein-protein interactions mediated by short linear motifs using a peptide library screening approach.

The paper shows that blocking protein quality control degradation stabilizes DHFR indel variants, suggesting a therapeutic approach for protein misfolding diseases.

This paper investigates how MLH1 mutations affect protein stability and interaction with PMS2, identifying regions that influence these properties and distinguishing pathogenic from benign variants.

The paper develops a yeast-based protein folding sensor to study indel variants, finding that most tolerated indels occur in specific regions and that computational tools can predict their effects.