Sarah K. Gersing

The paper shows that blocking protein quality control degradation stabilizes DHFR indel variants, suggesting a therapeutic approach for protein misfolding diseases.

The paper characterizes GCK variants' effects on GKRP interaction using deep mutational scanning, identifying variants that specifically perturb interactions and reveal allosteric effects.

The paper introduces a stable disulfide bond in E. coli OPRT to measure cytosolic redox potential in yeast, finding it to be -300 mV with enhanced stability in glutathione reductase mutants.

The paper develops a yeast-based protein folding sensor to study indel variants, finding that most tolerated indels occur in specific regions and that computational tools can predict their effects.

This study maps human glucokinase variant activity using a yeast complementation assay, identifying activity patterns linked to disease and providing insights for variant interpretation and therapeutic development.

This study investigates the effects of replacing water with heavy water (D2O) on fission yeast, revealing pleiotropic effects and highlighting the cell integrity pathway's role in D2O tolerance.