Cancer BiologyEMBO ReportsPeer-reviewed
Transcriptomic alterations including p53 pathway dysregulation prime DNMT3A mutant cells for transformation
Erin Lawrence, Amali Cooray, Andrew J. Kueh…·Marco J. Herold
This study shows DNMT3A mutations reduce DNA methylation and disrupt p53 pathway, increasing self-renewal and cancer risk in hematopoietic cells.
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