Jinjin Guo

The paper compares single-cell chromatin and gene expression data from human and mouse kidney development to identify conserved and divergent features and human-specific enhancer regions linked to kidney disease.

This paper develops a synthetic niche to expand nephron progenitor cells, enabling organoid generation and CRISPR screening for kidney development and disease.

The paper identifies androgen receptor-mediated regulation of sexually dimorphic gene expression in the mouse kidney and finds limited conservation in human kidney.

The paper uses single-cell RNA sequencing and lineage tracing in mouse kidneys to reveal sex differences, cell diversity, and lineage convergence in nephron development.