Biao Huang

This paper develops a synthetic niche to expand nephron progenitor cells, enabling organoid generation and CRISPR screening for kidney development and disease.

The paper shows transcript errors generate amyloid and prion-like proteins in human cells, linking DNA damage to aging and disease.

The paper estimates transcription fidelity in human cells, identifies factors controlling its accuracy, and links transcription errors to Alzheimer's disease progression.

The paper generates kidney collecting duct organoids from ureteric bud progenitors and stem cells to study development and disease of the collecting system.