Nils O. Lindström

Axial Nephron Fate Switching Demonstrates a Plastic System Tunable on Demand

The paper demonstrates that human nephron cells can switch between proximal and distal identities through WNT, FGF, and BMP signaling, showing developmental plasticity.

Comparative analysis of Xenopus mesonephric transcriptomics: Conservation of the developmental lineage of nephron stages

This study maps the single-cell transcriptomic landscape of Xenopus laevis mesonephros, revealing conserved nephron segment identities and differentiation programs across vertebrate kidney forms.

Defining and Controlling Axial Nephron Patterning in Human Kidney Organoids with Synthetic Wnt-Secreting Organizers

This study defines axial nephron patterning in human kidney organoids by using synthetic Wnt-secreting organizers to mimic developmental signals and achieve in vivo-like polarity.

Comparative single-cell analyses identify shared and divergent features of human and mouse kidney development

The paper compares single-cell chromatin and gene expression data from human and mouse kidney development to identify conserved and divergent features and human-specific enhancer regions linked to kidney disease.

Stepwise developmental mimicry generates proximal-biased kidney organoids

This paper develops a method to generate proximal tubule precursor cells in kidney organoids using transient Notch signaling activation, showing functional maturity and injury response.

A mechanical pacemaker sets rhythmic nephron formation in the kidney

This study identifies a mechanical pacemaker in the kidney stroma that synchronizes nephron formation with ureteric bud branching.

Canonical Wnt transcriptional complexes are essential for induction of nephrogenesis but not maintenance or proliferation of nephron progenitors

The paper investigates the role of canonical Wnt transcriptional complexes in nephron progenitor cell regulation, finding distinct roles in induction versus maintenance of nephrogenesis.

Modeling kidney development, disease, and plasticity with clonal expandable nephron progenitor cells and nephron organoids

This paper develops a synthetic niche to expand nephron progenitor cells, enabling organoid generation and CRISPR screening for kidney development and disease.

A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells

The paper shows that β-catenin modulates TCF/LEF binding at gene targets, switching from inhibitory to activating complexes during nephron progenitor cell differentiation.

Single Cell Profiling Reveals Sex, Lineage and Regional Diversity in the Mouse Kidney

The paper uses single-cell RNA sequencing and lineage tracing in mouse kidneys to reveal sex differences, cell diversity, and lineage convergence in nephron development.