Zhongwei Li

Modeling kidney development, disease, and plasticity with clonal expandable nephron progenitor cells and nephron organoids

This paper develops a synthetic niche to expand nephron progenitor cells, enabling organoid generation and CRISPR screening for kidney development and disease.

Transcript errors generate a continuous stream of amyloid and prion-like proteins in human cells

The paper shows transcript errors generate amyloid and prion-like proteins in human cells, linking DNA damage to aging and disease.

The fidelity of transcription in human cells

The paper estimates transcription fidelity in human cells, identifies factors controlling its accuracy, and links transcription errors to Alzheimer's disease progression.

Generation of kidney ureteric bud and collecting duct organoids that recapitulate kidney branching morphogenesis

The paper generates kidney collecting duct organoids from ureteric bud progenitors and stem cells to study development and disease of the collecting system.