NeuroscienceProceedings of the National Academy of SciencesPeer-reviewed
Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol
Hao Wang, Joshua A. Kulas, Chao Wang…·Scott B. Hansen
The paper shows astrocyte-derived cholesterol regulates amyloid precursor protein trafficking to lipid rafts, affecting Aβ and sAPP production in neurons, and disrupting cholesterol synthesis reduces amyloid pathology in mice.