Adam W. Smith

The paper presents structures of TAM receptor-ligand complexes with and without lipid, showing lipid stabilizes active complexes and provides a mechanism for TAM receptor activation.

This study uses PIE-FCCS to show that PIP2 enhances EGFR and EphA2 multimerization in live cells, revealing a role for anionic lipids in RTK interactions.

This study uses PIE-FCCS to show HER4 directly interacts with all HER family members in live cells, even without ligands, suggesting HER4 is a preferred dimerization partner.