A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription
Anna Minello, Jesús Gómez-Escudero, Sree Rama Chaitanya Sridhara, Charlotte A. Martin, Elodie Girard, Juan C. Cañas, Yasin Memari, Maria Rose Bustos, Antonio Galarreta, Virginie Boucherit, Evgeny Imyanitov, Sigríður Klara Böðvarsdóttir, Sylvain Baulande, Anne Vincent‐Salomon, Nicolas Servant, , Aura Carreira
The paper investigates a BRCA2 truncating variant's effect on NF-κB-driven transcription by showing it disrupts the BRCA2-PCAF complex, reducing histone acetylation and impairing cell migration.
Nature Communications · Dec 10, 2025Peer-reviewedCancer Biology