Author

Juan C. Cañas

Centro de Biología Molecular Severo OchoaORCID 0000-0002-2043-8160Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Aura CarreiraiD· 2 shared Anastasiia Skobelkina· 1 shared Angelos ConstantinouiD· 1 shared Anna MinelloiD· 1 shared Anne Vincent‐SalomoniD· 1 shared Antonio GalarretaiD· 1 shared Avelino BuenoiD· 1 shared Charlotte A. MartiniD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

Aura CarreiraORCID

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3 papers

Recent·Most cited

Cancer BiologyNature CommunicationsPeer-reviewedDec 10, 2025

A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription

Anna Minello, Jesús Gómez-Escudero, Sree Rama Chaitanya Sridhara…·Aura Carreira

The paper investigates a BRCA2 truncating variant's effect on NF-κB-driven transcription by showing it disrupts the BRCA2-PCAF complex, reducing histone acetylation and impairing cell migration.

2 citations

humanbulk RNA-seq

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Cell BiologyNucleic Acids ResearchPeer-reviewedJun 6, 2025

KIF2C-induced nuclear condensation concentrates PLK1 and phosphorylated BRCA2 at the kinetochore microtubules in mitosis

Anastasiia Skobelkina, Manon Julien, Sylvain Jeannin…·Sophie Zinn‐Justin

The paper shows KIF2C forms condensates during mitosis that concentrate PLK1 and phosphorylated BRCA2 at kinetochore microtubules, enhancing their kinase activity and attachment stability.

1 citation

humanexperimental assay

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Molecular BiologybioRxivPreprintJan 21, 2024

Strand asymmetry of DNA damage tolerance mechanisms

Juan C. Cañas, Dolores Jurado-Santiago, Mohammed Al Mamun…·Rodrigo Bermejo

The paper reveals an asymmetric response of DNA damage tolerance mechanisms to leading and lagging strand polymerase stalling.

3 citations

DNA methylationstatistical model

𝕏 PostBluesky