Cancer BiologyNature CommunicationsPeer-reviewed
A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription
Anna Minello, Jesús Gómez-Escudero, Sree Rama Chaitanya Sridhara…·Aura Carreira
The paper investigates a BRCA2 truncating variant's effect on NF-κB-driven transcription by showing it disrupts the BRCA2-PCAF complex, reducing histone acetylation and impairing cell migration.
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