PITHD1: An Endogenous Inhibitor of the 26S Proteasome During Cellular Dormancy
Sascha Josef Amann, Ken C. Dong, Josef Roehsner, Dominik Krall, Irina Grishkovskaya, Harald Kotisch, Alexander Schleiffer, Elisabeth Roitinger, Andrea Pauli, Andreas Martin, David Haselbach
The paper identifies PITHD1 as an endogenous inhibitor of the 26S proteasome in dormant cells, revealing a triple-lock mechanism that prevents protein degradation during cellular dormancy.
bioRxiv · Dec 4, 2024 · PreprintBiochemistry