Author

Harald Kotisch

Research Institute of Molecular PathologyORCID 0000-0003-1684-5211Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:zebrafish· 1

Frequent Co-Authors

David HaselbachiD· 2 shared Irina GrishkovskayaiD· 2 shared Achim DickmannsiD· 1 shared Alexander SchleifferiD· 1 shared Andrea PauliiD· 1 shared Andreas MartiniD· 1 shared Dominik KralliD· 1 shared Elisabeth RoitingeriD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersMolecular Biology

David HaselbachORCID

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2 papers

Recent·Most cited

Molecular BiologyNature CommunicationsPeer-reviewedFeb 4, 2026

A multivalent adaptor mechanism drives the nuclear import of proteasomes

Hanna L. Brunner, Robert Kalis, Lorenz Grundmann…·David Haselbach

The paper identifies AKIRIN2 as a multivalent adaptor protein that coordinates proteasome nuclear import through a stepwise assembly of importin clusters.

3 citations

experimental assay

𝕏 PostBluesky

BiochemistrybioRxivPreprintDec 4, 2024

PITHD1: An Endogenous Inhibitor of the 26S Proteasome During Cellular Dormancy

Sascha Josef Amann, Ken C. Dong, Josef Roehsner…·David Haselbach

The paper identifies PITHD1 as an endogenous inhibitor of the 26S proteasome in dormant cells, revealing a triple-lock mechanism that prevents protein degradation during cellular dormancy.

6 citations

zebrafishexperimental assay

𝕏 PostBluesky