Elisabeth Roitinger

Emergence of histone-based chromatin complexity in Asgard archaea

This study identifies histone-based chromatin regulation components in Asgard archaea, suggesting these features predate eukaryogenesis.

The SPARK complex forms the molecular basis of vertebrate fertilization

This study identifies SPARK as a conserved multi-protein complex essential for vertebrate fertilization, linking gamete recognition to membrane fusion.

RNA decay via the nuclear exosome is essential for piwi-mediated transposon silencing

The paper shows that the Drosophila Piwi-piRNA pathway silences transposons by degrading their RNA via the nuclear exosome, with TEsup proteins facilitating this process.

Cross-species interactome analysis uncovers a conserved selective autophagy mechanism for protein quality control in plants

The paper identifies a conserved selective autophagy receptor, CESAR, critical for proteostasis under heat stress in plants through cross-species interactome analysis.

A moss N-Acetyltransferase-MAPK protein controls 2D to 3D developmental transition via acetylation and phosphorylation changes

This study identifies a moss protein with dual acetylation and phosphorylation domains that regulates the 2D-to-3D developmental transition through PTM-mediated metabolic reprogramming.

Hierarchical assembly and functional resilience of the mammalian RNA exosome

The paper investigates the assembly and functional resilience of the RNA exosome in mouse embryonic stem cells using CRISPR/Cas9, revealing a hierarchical assembly pathway and quality control mechanisms.

PITHD1: An Endogenous Inhibitor of the 26S Proteasome During Cellular Dormancy

The paper identifies PITHD1 as an endogenous inhibitor of the 26S proteasome in dormant cells, revealing a triple-lock mechanism that prevents protein degradation during cellular dormancy.

A conserved fertilization complex of Izumo1, Spaca6, and Tmem81 mediates sperm-egg interaction in vertebrates

The paper identifies a conserved trimeric complex of Izumo1, Spaca6, and Tmem81 essential for sperm-egg interaction in vertebrates, showing their role in male fertility and binding to the egg protein Bouncer.

Increase in ER-mitochondria contacts and mitochondrial fusion are hallmarks of mitochondrial activation during embryogenesis

The paper profiles mitochondrial activity, morphology, and associated molecular changes during zebrafish embryogenesis, identifying increased ER-mitochondria contacts and mitochondrial fusion as key contributors to mitochondrial activation.

Metabolic enzymes moonlight as selective autophagy receptors to protect plants against viral-induced cellular damage

This study shows that metabolic enzymes act as autophagy receptors in plants to degrade defense executors during viral infection, revealing autophagy as a tolerance pathway rather than an antiviral defense.

Functionally distinct promoter classes initiate transcription via different mechanisms reflected in focused versus dispersed initiation patterns

The paper shows that different promoter classes use distinct PIC compositions and mechanisms, leading to focused or dispersed transcription initiation patterns in Drosophila.