Alexander Schleiffer

The paper systematically identifies effector functions of pathogen ORFs across multiple pathways, revealing new roles for known effectors and uncharacterized proteins.

This study identifies a DDK/CDK-12/DNA-2 signaling axis that promotes meiotic DNA end resection in C. elegans, preventing aberrant recombination outcomes.

This study identifies SPARK as a conserved multi-protein complex essential for vertebrate fertilization, linking gamete recognition to membrane fusion.

The paper presents the cryo-EM structure of the UBR4 complex, revealing its architecture and mechanism for substrate binding and ubiquitin chain extension in protein quality control.

This study identifies CLEC18A as a regulator of clear cell renal cell carcinoma progression by interacting with sulfated GAGs and shows its expression is linked to improved patient survival.

The paper identifies PITHD1 as an endogenous inhibitor of the 26S proteasome in dormant cells, revealing a triple-lock mechanism that prevents protein degradation during cellular dormancy.

The paper identifies a conserved trimeric complex of Izumo1, Spaca6, and Tmem81 essential for sperm-egg interaction in vertebrates, showing their role in male fertility and binding to the egg protein Bouncer.

This study identifies an amino acid change in the HP1 protein Rhino that disrupts its interaction with Kipferl, altering chromatin binding and piRNA profiles in Drosophila.

The paper identifies specific amino acid residues and N-glycosylation patterns in Bouncer proteins that mediate species-specific sperm-egg compatibility between medaka and zebrafish.

The paper identifies and characterizes repressive domains in Drosophila transcription factors using a new high-throughput method, revealing conserved motifs and co-repressor interactions.

This study shows that zebrafish Spaca6 is essential for fertilization by regulating Dcst2 levels and enabling sperm-egg membrane binding.

This study identifies Ski7 as a post-transcriptional regulator that maintains low transcript levels of specific genes during the zebrafish oocyte-to-embryo transition, impacting fertility and redox processes.

This study identifies Bouncer, a Ly6/uPAR protein in zebrafish oocytes, as essential for species-specific fertilization and shows it can enable cross-species fertilization between zebrafish and medaka.