Jan Mikelson

The paper uses optogenetic actuator and ERK biosensor circuits to study MAPK network dynamics and identifies RSK2-mediated feedback as critical for ERK regulation and drug response.

This paper introduces a likelihood-free nested sampling method for Bayesian inference in stochastic biochemical reaction networks, providing an unbiased evidence estimator and posterior samples with a novel termination criterion.

The paper uses temporal perturbations of Erk dynamics to reveal the network architecture of FGF2-MAPK signaling and how it influences cell fate decisions.