Marc‐Antoine Jacques

An integrated single cell and spatial omics atlas of human prenatal development

Human Developmental Cell Atlas integrates ~4.6 million cells/nuclei from 4-22 post-conception weeks into 454 refined cell types and maps 114 spatial niches across 6PCW whole-embryo sections.

Comparative Biology at Single-Cell Resolution: Rigorous Matching of Atlases for Cross-Species Analysis

RIMA enables cross-species comparison of transcriptomic atlases, identifying conserved developmental programs and revealing species-specific differences in gene expression timing.

Spatiotemporal map of the developing human reproductive tract at single-cell resolution

This study creates a single-cell spatial atlas of the developing human reproductive tract, identifying genes and mechanisms involved in sexual dimorphism and organ development.

Systems-level transcriptional regulation of Caenorhabditis elegans metabolism

The paper identifies widespread transcriptional regulation of metabolic genes in C. elegans and introduces a tool to explore gene-pathway associations.

Optogenetic actuator/ERK biosensor circuits identify MAPK network nodes that shape ERK dynamics

The paper uses optogenetic actuator and ERK biosensor circuits to study MAPK network dynamics and identifies RSK2-mediated feedback as critical for ERK regulation and drug response.

Temporal perturbation of Erk dynamics reveals network architecture of FGF2-MAPK signaling

The paper uses temporal perturbations of Erk dynamics to reveal the network architecture of FGF2-MAPK signaling and how it influences cell fate decisions.