Olivier C. Pertz

This paper reviews current smart microscopy implementations and proposes a framework for interoperability to improve collaboration and standardization in the field.

This study uses optogenetic tools to reveal distinct functional roles of SRC and HCK kinases in macrophages, despite their redundancy.

The paper studies acto-myosin dynamics and Rho GTPase interactions in epithelial cells using live microscopy and theory, revealing wave propagation and annihilation mechanisms.

ARCOS.px tracks spatial clusters in time-lapse microscopy to study dynamic cellular structures and their interactions.

This paper introduces a real-time feedback system for optogenetic targeting, enabling automated and adaptive stimulation based on live cell behavior.

The paper shows that myosin cluster dynamics in multi-cellular epithelial wound rings are conserved with single-cell cytokinetic rings and can predict stress generation and shape changes during morphogenesis.

This paper introduces a low-cost microfabrication method using 3D printing and repurposed microscopes for biological applications, achieving micrometer precision without clean room infrastructure.

Convpaint provides an interactive pixel classification framework using pretrained CNNs or ViTs, integrated into the napari ecosystem for versatile image processing.

This study shows ARHGEF17 regulates actomyosin network disassembly by localizing at the lamella back and promoting RhoA activity through feedback mechanisms.

This study shows RhoA signaling has both inhibitory and stimulatory effects on axon development depending on timing, location, and downstream effectors.

This paper introduces ADeS, a deep learning system for detecting apoptosis in live-cell imaging with high accuracy and robustness across diverse conditions.

The paper quantifies the information transmission rate of the MAPK/ERK pathway, finding it can transmit at least 6 bits per hour.

The paper uses optogenetic actuator and ERK biosensor circuits to study MAPK network dynamics and identifies RSK2-mediated feedback as critical for ERK regulation and drug response.

The paper uses temporal perturbations of Erk dynamics to reveal the network architecture of FGF2-MAPK signaling and how it influences cell fate decisions.