Guoping Fan

The paper links cellular developmental potency to genomic transcriptional potency, showing that gene occlusion via chromatinization restricts lineage potential.

The paper identifies gene occlusion erasure as a defining difference between naive and primed pluripotency states, showing Esrrb-dependent deocclusion sustains naive pluripotency.

The paper examines X-chromosome dosage compensation in human embryos, finding balanced X:A ratios and XCI starting at day 6-7 blastocyst stage.

scCAT-seq identifies and quantifies single-cell RNA isoforms using short-read sequencing, revealing novel transcripts and cell-type specific isoforms in DRG neurons and oocytes.

The paper uses single-cell multi-omics to show DNA methylation changes in DRG neurons correlate with age and injury responses, particularly in Notch signaling and regeneration-associated genes.

This paper discusses challenges and future directions in single-cell analysis, highlighting advances in technologies and computational methods for studying cellular heterogeneity.