Author

Bogdan I. Fedeles

Massachusetts Institute of TechnologyORCID 0000-0001-5252-826XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Alexander S. BrodskyiD· 1 shared Andrea SchmidtiD· 1 shared Ann C. MladekiD· 1 shared Ayush BharatiiD· 1 shared Bin WuiD· 1 shared Cécile Riviere-CazauxiD· 1 shared Choi‐Fong ChoiD· 1 shared Danielle M. BurgenskeiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

Alexander S. BrodskyORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintNov 10, 2025

Systems analysis uncovers early temozolomide responses and peptide antigens in glioblastoma

Elizabeth Y. Choe, Owen K. Leddy, Cécile Riviere-Cazaux…·Forest M. White

This study uses a multi-omics approach to analyze early TMZ responses in GBM cells, identifying TMZ-associated peptide antigens and immune-related changes.

DOI 10.1101/2025.11.10.687735

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologyScience AdvancesPeer-reviewedFeb 26, 2025

Modulation of blood-tumor barrier transcriptional programs improves intra-tumoral drug delivery and potentiates chemotherapy in GBM

Jorge L. Jimenez-Macias, Philippa C. Vaughn-Beaucaire, Ayush Bharati…·Sean Edward Lawler

This study identifies a 12-gene BTB signature, shows CDH5 as a core component, and demonstrates that BIA disrupts the BTB to enhance chemotherapy delivery and efficacy in GBM.

24 citationstop 1%

humanspatial transcriptomics

𝕏 PostBluesky