Geoffrey R. Hill

This study shows that increasing BCMA density with GSI improves CAR T cell cytotoxicity but also enhances trogocytosis, leading to CAR T cell dysfunction and exhaustion.

The paper introduces a computational framework to efficiently identify significantly neighbor enriched TCR sequences, demonstrating its utility in analyzing memory T cells and T cell responses to vaccination and viral infections.

This paper shows that pretransplant targeting of TNFRSF25 and CD25 with a TL1A-Ig fusion protein and low-dose IL-2 expands recipient Tregs, reducing GVHD after HSCT while preserving GVL.