Author

Daniel E. Larcombe

University of StrathclydeORCID 0000-0001-5286-1978Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Paul A. HoskissoniD· 2 shared Adriana BizioriD· 1 shared Andrew J. Collis· 1 shared Angelika B. KiepasiD· 1 shared Arnaud JavelleiD· 1 shared Barrie M. WilkinsoniD· 1 shared Benjamin D. HuckleiD· 1 shared Benjamin F CooperiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Paul A. HoskissonORCID

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2 papers

Recent·Most cited

A bacterial Rhesus transporter retunes a structurally conserved ammonium pore into a reversible nitrogen valve

Adriana Bizior, Mingyu Qin, Peter J. F. Henderson, Benjamin F Cooper, Daniel E. Larcombe, Paul A. Hoskisson, Georgia L. Isom, Leighton Pritchard, Syma Khalid, Arnaud Javelle

This study shows how a bacterial Rhesus transporter modifies a conserved ammonium pore to function as a reversible nitrogen valve through specific residue changes.

bioRxiv · Sep 24, 2026 · PreprintBiochemistry

Genome evolution during the domestication of an antibiotic-producing Streptomyces strain

John Munnoch, Daniel E. Larcombe, Rebecca E. McHugh, John Bruce, Kirsty Robb, James T Croxford, Angelika B. Kiepas, Juan Pablo Gomez‐Escribano, Nicola A. Crowhurst, Andrew J. Collis, Steven G. Kendrew, Benjamin D. Huckle, Barrie M. Wilkinson, Iain S. Hunter, Paul A. Hoskisson

This study analyzes genomic changes in Streptomyces clavuligerus strains during domestication, showing how mutations and rearrangements enhance antibiotic production while reducing metabolic flexibility.

bioRxiv · Aug 28, 2026 · PreprintMicrobiology