BiochemistrybioRxivPreprint
Femtosecond pulsed laser ablation for in-tissue electron cryo-tomography
Jake L. R. Smith, Renae N. Gannon, Calina A. Glynn…·Michael Grange
This paper demonstrates that cryogenic femtosecond pulsed laser ablation can efficiently prepare vitreous specimens of mammalian brain tissue for cryo-ET, enabling routine in situ cell biology of multicellular samples.
DOI 10.64898/2026.10.28.761815