James H. Naismith

This paper demonstrates that cryogenic femtosecond pulsed laser ablation can efficiently prepare vitreous specimens of mammalian brain tissue for cryo-ET, enabling routine in situ cell biology of multicellular samples.

This paper develops a method to isolate and characterize SMAPs from NK-92 cells, showing their cytotoxic activity against tumor cells in vitro and in vivo.

This paper reduces SEM charging artefacts in cryogenic biological samples using interleaved scanning, enabling clearer visualization of previously masked structures.

This paper demonstrates xenon plasma focused ion beam milling for preparing high-pressure frozen specimens, achieving a 4.0 Å E. coli ribosome structure with minimal structural damage beyond 45 nm.