Author

Abraham Shim

Memorial Sloan Kettering Cancer CenterORCID 0000-0001-5351-0774Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2

Frequent Co-Authors

John MaciejowskiiD· 2 shared Wen ZhouiD· 2 shared Xiaohan LuaniD· 2 shared Alex KentsisiD· 1 shared Ashley NicholsiD· 1 shared Eléonore ToufektchaniD· 1 shared Hannah Rosenberg· 1 shared James H. HicklingiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

John MaciejowskiORCID

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2 papers

Recent·Most cited

Molecular BiologyMolecular CellPeer-reviewedMar 1, 2026

ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei

Yanyang Chen, R. M. Norman, Eléonore Toufektchan…·John Maciejowski

The paper identifies BAF as a barrier that restricts TREX1 access to micronuclei, explaining the need for ER-tethering to enable TREX1 entry and suppress cGAS activation.

5 citationstop 2%

humanexperimental assay

𝕏 PostBluesky

GeneticsHuman Molecular GeneticsPeer-reviewedMay 22, 2024

Mutations in the non-catalytic polyproline motif destabilize TREX1 and amplify cGAS-STING signaling

Abraham Shim, Xiaohan Luan, Wen Zhou…·John Maciejowski

This study shows that TREX1 mutations in the polyproline motif destabilize the protein, leading to excessive cGAS-STING signaling and autoimmune disease.

10 citations

humanexperimental assay

𝕏 PostBluesky