Cancer BiologyPharmacological ResearchPeer-reviewed
Resistance to BRAF inhibitors drives melanoma sensitivity to Chk1 inhibition
Danielle Gonçalves de Carvalho, Juliana C.N. Kenski, Daniel Andrade Moreira…·Patrícia A. Possik
This study shows BRAF inhibitor-resistant melanoma cells are more sensitive to Chk1 inhibition due to increased replication stress, suggesting Chk1i could overcome MAPK inhibitor resistance.
4 citations