Patrícia A. Possik

This study identifies HOXD13 as a driver of a developmental program in melanoma that promotes angiogenesis and suppresses T-cell infiltration through a gene regulatory axis involving VEGFA, SEMA3A, and CD73.

SiteCELL enables on-site purification and cryopreservation of PBMCs for immune single cell profiling, performing as well as Ficoll density gradient in both lab and rural settings.

This study shows BRAF inhibitor-resistant melanoma cells are more sensitive to Chk1 inhibition due to increased replication stress, suggesting Chk1i could overcome MAPK inhibitor resistance.

This study identifies immunological differences in ulcerated acral melanoma, showing increased humoral immunity and inflammation markers, and proposes potential therapeutic targets.

This study analyzes acral melanoma genomes and transcriptomes from Mexican patients, finding ancestry-related mutation patterns and survival differences.