Daniel S. Peeper

This paper introduces a SILAC-TMT-RTS method to study proteome changes in T cell-cancer cell co-cultures, revealing mechanisms of differential sensitivity to T cell killing.

This study shows BRAF inhibitor-resistant melanoma cells are more sensitive to Chk1 inhibition due to increased replication stress, suggesting Chk1i could overcome MAPK inhibitor resistance.

This study shows that inhibiting TBK1/IKKe-mediated RIPK1 phosphorylation increases tumor sensitivity to immune cell killing by disrupting TNF signaling.